Synthesis of 3-(Alkylthio and Phenylthio)-1,1,1-trifluoroalkan-2-ones via Ring Opening of Epoxy Ethers

Abstract

Regioselective ring opening of 1-trifluoromethyl epoxy ethers 2 was achieved with alkyl and phenyl sodium thiolates to afford new 3-(alkylthio and phenylthio)-1,1,1-trifluoroalkan-2-ones 3-5 in good yields.