Concise Approach to Novel Isothiazolidinone Phosphotyrosine Mimetics: Microwave-Assisted Addition of Bisulfite to Activated Olefins

Abstract

[reaction: see text] A novel and efficient synthesis of isothiazolidinone protein tyrosine phosphatase mimetics is presented. A practical, regiospecific microwave-assisted addition of bisulfite to activated olefins, including unprecedented reactions with styrene derivatives, is highlighted.