Transition Metal‐Catalyzed Annulation Reactions, VII. Palladium‐Catalyzed CH Activation at Methoxy Groups: Regiochemistry of the Domino Coupling Process

Abstract

Abstract By palladium catalysis substituted ortho‐ iodoanisoles ( 5, 8, 10, 13 ) are transformed either to annulated pyran ( 6 ) or furan derivatives ( 7, 9, 11, 14, 15 ), depending on the reactivity of additional substituents. The regiochemistry of the domino coupling processes is analyzed and a mechanistic rationale developed. Key step is the CH activation at methoxy groups.