Rapid Synthesis of Matrix Metalloproteinase Inhibitors via Ugi Four-Component Condensation

Abstract

By employing ammonia, together with a mono succinate ester, an aldehyde and an isonitrile in the Ugi four-component condensation the basic structure of pseudopeptide succinyl matrix metalloproteinase inhibitors is constructed in a single step. Deprotection of the ester provides the carboxylic acid zinc(II) binding group required for biological activity.