Chiral toluene-2,α-sultam auxiliaries: Asymmetric alkylations, acylations and aldolizations of N-acyl derivatives

Bornane sultam-directed asymmetric synthesis of crystalline, enantiomerically pure syn aldols

Wolfgang Oppolzer, Julian Blagg, Inés Rodríguez et al. · Journal of the American Chemical Society · 1990 · 238 citations · Full text

Natural Sciences, Chemistry, Drug Discovery +10

Asymmetric acylation reactions of chiral imide enolates. The first direct approach to the construction of chiral .beta.-dicarbonyl synthons

David A. Evans, Michael D. Ennis, Tam Minh Le et al. · Journal of the American Chemical Society · 1984 · 207 citations

Natural Sciences, Chemistry, Catalysis +7

Asymmetric alkylation of N-acylsultams: A general route to enantiomerically pure, crystalline C(α,α)-disubstituted carboxylic acid derivatives

Wolfgang Oppolzer, Robert Moretti, Silvia Thomi · Tetrahedron Letters · 1989 · 182 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Asymmetric synthesis of α-amino acids and α-N-hydroxyamino acids via electrophilic amination of bornanesultam-derived enolates with 1-chloro-1-nitrosocyclohexane.

Wolfgang Oppolzer, Osamu Tamura · Tetrahedron Letters · 1990 · 127 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Asymmetric alkylations of a sultam-derived glycinate equivalent: practical preparation of enantiomerically pure α-amino acids

Wolfgang Oppolzer, Robert Moretti, Silvia Thomi · Tetrahedron Letters · 1989 · 104 citations

Pharmacy, Medicinal Chemistry, Pharmacology +4