A New and Convenient One-StepSynthesis of the Natural 3-Deoxyanthocyanidins Apigeninidinand Luteolinidin Chlorides from 2,4,6-Triacetoxybenzaldehyde

Abstract

The total synthesis of apigeninidin (1),luteolinidin (2) and 5,7-dihydroxyflavylium(5) chlorides is performed through a onestep reaction from an acetylated derivative of a commercial reagent.Condensation reaction between 2,4,6-triacetoxybenzaldehyde and anacetophenone derivative in anhyd methanolic hydrogen chloride providesthe 3-deoxyanthocyanidins in high yields.