Organic Letters · 1999 · 273 citations · 11 references
Natural SciencesChemistryOrganic ChemistryHeterocyclic ChemistryMacrocycle SynthesisOrganic SynthesisSolvent-free SynthesisAldehydesPyrrole ChemistrySolvent-free Condensation Reactions
The solvent-free condensation of pyrrole and pentafluorobenzaldehyde (and to a lesser extent other electron-poor aldehydes as well) leads to a variety of products, of which three have been isolated and fully characterized. The two main products (11% each) are an open-chain pentapyrrole and corrole, a tetrapyrrolic macrocycle.
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Refined Synthesis of 5-Substituted Dipyrromethanes
Benjamin J. Littler, Mark A. Miller, Chen‐Hsiung Hung et al. · The Journal of Organic Chemistry · 1999 · 441 citations