Synthesis and cytotoxic activity of 2‐dialkylamino‐alkyl‐1,3‐dihydropyrrolo[3,4‐<i>c</i>]quinoline‐1,3‐diones and 6‐(2‐dimethylaminoethyl)‐1<i>H</i>‐dibenz[<i>c,e</i>]azepine‐5,7‐dione

Abstract

Abstract The title compounds were synthesized. Cyclodehydration of aromatic 1,2‐dicarboxylic acids, in the presence of dicyclohexylcarbodiimide, to the corresponding N ‐substituted imides is discussed. Compounds 8 and 10 were tested in vitro against K562 and HL‐60 cell lines. Compound 10 exhibited moderate cytotoxic activity.