Heterocycles · 2010 · 11 citations · 15 references
Effective One-pot SynthesisEngineeringInexpensive ReagentsOrganic ChemistryCatalysisStereoselective SynthesisChemistryHeterocycle ChemistryPoly-substituted QuinolinesSynthetic ChemistryEnantioselective Synthesis
A highly effective one-pot synthesis of poly-substituted quinolines from 2-alkynylnitrobenzenes using inexpensive reagents has been developed.Reaction of 2-alkynylnitrobenzenes with Sn/HCl in EtOH resulted in the formation of 2-aminophenyl ketones and subsequently condensed in situ with ketones to form tri-substituted quinolines in 80-97% yields.
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A Practical, Metal-Free Synthesis of 1<i>H</i>-Indazoles
Carla M. Counceller, Chad C. Eichman, Brenda C. Wray et al. · Organic Letters · 2008 · 107 citations
Experimental Synthesis, Metal-free Synthesis, Heterocyclic +10