The First Rapid Palladium-Catalyzed Aminations of (Azahetero)aryl Chlorides under Temperature-Controlled Microwave Heating - Concepedia

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The First Rapid Palladium-Catalyzed Aminations of (Azahetero)aryl Chlorides under Temperature-Controlled Microwave Heating

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2003

Year

Bert U. Maes, Kristof T. J. Loones, Guy L. F. Lemière, R. Dommisse

Chemical EngineeringPalladium-catalyzed AminationsEngineeringCross-coupling ReactionTemperature-controlled Microwave HeatingCatalytic SynthesisOrganic ChemistryOrganometallic CatalysisCatalysisChemistrySynthesis MethodMicrowave SynthesisUnactivated Aryl Chlorides

Abstract

Fast palladium-catalyzed aminations of activated and unactivated azaheteroaryl chlorides as well as unactivated aryl chlorides have been achieved using temperature-controlled microwave heating. Good yields (75-91%) were obtained in a reaction time of only 10 minutes.