Publication | Closed Access
One-Carbon Homologation of Carboxylic Acids via BtCH<sub>2</sub>TMS: A Safe Alternative to the Arndt−Eistert Reaction
37
Citations
20
References
2001
Year
Carboxylic AcidsEngineeringBiochemistryOne-carbon HomologationCorresponding Homologated AcidsSafe AlternativeNatural SciencesOrganic ChemistryOrganometallic CatalysisCatalysisOne-carbon SynthonChemistryStereoselective SynthesisAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
Carboxylic acids are converted into the corresponding homologated acids or esters, using easily available 1-(trimethylsilylmethyl)benzotriazole (1) as a one-carbon synthon. The effectiveness of the reaction has been investigated on six aryl and seven alkyl carboxylic acids.
| Year | Citations | |
|---|---|---|
Page 1
Page 1