Publication | Closed Access
Synthesis and anaerobic activity of novel 1-carba-1-dethiacephalosporins
10
Citations
0
References
1993
Year
Bioorganic ChemistryKlebsiella PneumoniaeAnaerobic PathogensLead CompoundPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryBiosynthesisNovel 1-Carba-1-dethiacephalosporinsAntimicrobial ResistanceBiotransformationBiochemistryAntibacterial AgentAntimicrobial CompoundPharmacologyClinical MicrobiologyNatural SciencesMicrobiologyMedicine
The synthesis and biological evaluation of novel 1-carba-1-dethiacephalosporins exhibiting activity against anaerobic pathogens are described. The nitrothiazole substituent was determined to be crucial to maintaining this activity. The pharmacokinetic parameters and initial toxicological profile of the lead compound are discussed.