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Gas-Phase Pyrolysis in Organic Synthesis: Rapid Green Synthesis of 4-Quinolinones
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2007
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Acid DerivativesChemical EngineeringEnantioselective SynthesisEngineeringBiochemistryNatural SciencesGreen ChemistrySustainable SynthesisAminomethylene Meldrum ’Organic ChemistryCatalysisSynthetic ChemistryChemistrySynthesis MethodStereoselective SynthesisRapid Green SynthesisGas-phase PyrolysisCatalytic Synthesis
Gas-phase pyrolysis of aminomethylene Meldrum’s acid derivatives gave quinolinones and/or amines depending on the nature of arylamino moiety. Effect of substituent on reaction rate and nature of pyrolysis products supports the suggested intramolecular nucleophilic substitution reaction via initially formed keteneamine intermediate.