Synthesis of a C-9 to C-18 Building Block of the Phenalamides

Abstract

In the context of a synthesis of phenalamide A2, the C-9 to C-18 building block 6 was synthesized. The stereogenic centers were generated by alkylation of an Evans oxazolidinone 12 and by a crotylboration reaction using the enantiomerically pure (E)-α-chlorocrotylboronate (4).