Hetero Diels–Alder trapping of 3-methylene-1,2,4-[3H]naphthalenetrione: an efficient protocol for the synthesis of α- and β-lapachone derivatives

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.

Sarah M. Planchon, Shelly M. Wuerzberger, Benjamín Frydman et al. · PubMed · 1995 · 205 citations · Full text

Medicine, Oncology, Pharmacology +17

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.

Benjamín Frydman, L J Marton, Jian‐Sheng Sun et al. · PubMed · 1997 · 153 citations

Medicine, Molecular Biology, Pharmacology +12

Induction of apoptosis by beta-lapachone in human prostate cancer cells.

Chiang J. Li, Chao Wang, Arthur B. Pardee · PubMed · 1995 · 143 citations

Medicine, Oncology, Pharmacology +15

.beta.-Lapachone: synthesis of derivatives and activities in tumor models

K. SCHAFFNER‐SABBA, K. H. Schmidt-Ruppin, W. Wehrli et al. · Journal of Medicinal Chemistry · 1984 · 114 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

LVII.—The constitution of “lapachic acid”(lapachol) and its derivatives

Samuel C. Hooker · Journal of the Chemical Society Transactions · 1892 · 77 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +2