Publication | Closed Access
An Efficient Synthesis of Chiral β-Hydroxy Sulfones via Ru-Catalyzed Enantioselective Hydrogenation in the Presence of Iodine
67
Citations
33
References
2007
Year
Asymmetric CatalysisChemical EngineeringAnhydrous HiEngineeringRu-catalyzed Enantioselective HydrogenationSulfonyl KetonesOperating AdditiveOrganic ChemistryCatalysisEfficient SynthesisChemistryHydrogenHomogeneous CatalysisMolecular CatalysisChiral β-Hydroxy SulfonesSynthetic ChemistryEnantioselective SynthesisCatalytic Synthesis
Ru-SUNPHOS catalyzed asymmetric hydrogenation of a variety of sulfonyl ketones (R = alkyl, aryl) in the presence of iodine gave enantioenriched hydroxyl sulfones with good catalytic efficiency. Further investigation revealed that the in situ generated anhydrous HI is the operating additive.
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