A New Selective Synthesis of the Ile-<i>a</i><i>llo</i>-Thr-Gly Tripeptide Fragment of Lysobactin

Abstract

[formula: see text] trans-Aziridine-2-carboxylic acid derivatives are useful intermediates for the synthesis of threonine or allo-threonine through ring expansion and SN2 displacement, respectively. We describe here the preparation of the Ile-allo-Thr-Gly 11 fragment of Lysobactin via the aziridine 9 intermediate.