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A Novel Synthetic Route to 1-Aminoalkylphosphinic Acids
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1994
Year
BiosynthesisBioorganic ChemistryNovel Synthetic RouteBiochemistryVarious 1-Aminoalkylphosphinic AcidsNatural SciencesEngineeringCorresponding BisPeptide SynthesisOrganic ChemistryHigh YieldStereoselective SynthesisChemistrySynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A "one-pot" synthesis of various 1-aminoalkylphosphinic acids is described. They were obtained in high yield by the deprotection of the corresponding bis(trimethylsilyl) N-tritylaminoalkylphosphites. The latter were prepared by addition of bis(trimethylsilyl) phosphonite to a Ntritylalkanimine.