Double C−H Activation Strategy for the Asymmetric Synthesis of <i>C</i>₂-Symmetric Anilines

Abstract

Rh(2)(S-DOSP)(4)-catalyzed C-H activation to N,N-dimethylanilines is described. A double C-H activation was possible by using an excess of methyl aryldiazoacetate, and this provided a very direct approach to C(2)-symmetric anilines. [reaction--see text]