Catalytic Enantioselective Synthesis of β2-Amino Acids This work was supported by the National Science Foundation (CHE 0092490) and the National Institutes of Health (GM57425).

Abstract

A very direct approach for the synthesis of β-amino esters is provided by catalytic asymmetric CH activation by means of carbenoid-induced CH insertion (see scheme; Boc=butyloxycarbonyl; TFA=trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular CH insertions occurring at a methyl site. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z18888_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.