Organic Letters · 1999 · 140 citations · 25 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganic ChemistryCross-coupling ReactionsMetal CatalysisMetal Ion CatalysisMetal-ligand BondingCross-coupling CatalysisMild Reaction ConditionsNickel CatalysisNickel-catalyzed Cross-couplingPalladium-catalyzed Cross-couplingTransition-metal-catalyzed Cross-coupling
The addition of Bu 4 NI has been found to accelerate the palladium(0)-catalyzed cross-coupling between benzylic zinc bromides and aryl or alkenyl triflates. Remarkably, it further allows a new nickel(0)-catalyzed cross-coupling between functionalized benzylic zinc reagents and primary alkyl iodides leading to polyfunctional products in good yields under mild reaction conditions (0−20 °C, 4−16 h).
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