Publication | Closed Access

Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile

Medicinal ChemistryBiochemistryImproved Cardiovascular ProfileMedicineNatural SciencesRational Drug DesignMechanism Of ActionPharmacological AgentPharmacotherapyPharmacologyPharmaceutical ChemistryCcr2 AntagonistDrug Discovery