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Novel Antitumor Acetamide, Pyrrole, Pyrrolopyrimidine, Thiocyanate, Hydrazone, Pyrazole, Isothiocyanate and Thiophene Derivatives Containing a Biologically Active Pyrazole Moiety
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2011
Year
Combinatorial ChemistryPharmaceutical ScienceBioorganic ChemistryReference DrugCas 23214-92-8PharmacotherapyPharmaceutical ChemistryMedicinal ChemistryAnti-cancer AgentTheantitumor ActivityBiochemistryNovel Antitumor AcetamidePharmacological AgentDrug DevelopmentThiophene DerivativesPharmacologyBiomolecular EngineeringNatural SciencesMedicineDerivative (Chemistry)Drug Discovery
4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide (sulfaphenazole) 1 was selected as strategic starting material for the synthesis of some novel acetamide 2, pyrrole 4, pyrrolo[2,3-d]pyrimidine 5, thiocyanate 6, hydrazone 7a,b pyrazole 8, isothiocyanate 9 and thiophene 12 derivatives to evaluate theantitumor activity. Compound 4 was more effective than the reference drug, doxorubicin (CAS 23214-92-8) as positive control.