Biologically Important Physicochemical Properties of Kojic Acid Derivatives

Abstract

Physicochemical properties (hydrophobicity, acidity, metal complexing ability), which are expected to play a role in biological activity of kojic acid derivatives, were determined for 35 compounds. The structure-property relationship were analysed with the aim to predict the properties of new derivatives and to obtain the data for formulation of quantitative structure-time-activity relationships. Linear correlations were found between hydrophobicity expressed as decadic logarithm of the 1-octanol/buffer partition coefficient and the sum of fragment constants and correlation factors according to Leo and Hansch as well as between acidity and a set of Hammett constants of the varying substituents.