Organic Letters · 2013 · 98 citations · 45 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCatalyst SynthesisChemical BondingCross-coupling ReactionsHeterocycle SynthesisOrganic SynthesisReaction MechanismsAsymmetric Heterocycle SynthesisC-h Bond ActivationIndolizine ChemistryMild Reaction ConditionsSolvent-free Catalysis
A new rare earth metal and samarium-catalyzed C(sp(3))-H bond activation is reported in which 2-alkylazaarenes and propargylic alcohols were converted to indolizines. This process operates under mild conditions and solvent-free conditions. A broad scope of coupling partners has been established, and a likely mechanism has also been suggested.
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