Publication | Open Access
Spongistatin synthetic studies. 3. Construction of the C(1–17) spiroketal
55
Citations
26
References
1997
Year
Combinatorial ChemistrySpongistatin Synthetic StudiesBioorganic ChemistryMacromolecular EngineeringBiochemistryAb-ring SubunitNatural SciencesEngineeringOrganic ChemistryJulia Sulfone Coupling/methylenationChemistryAntimitotic Polyether MacrolidesChemical BiologyNatural Product SynthesisSynthetic ChemistryBiomolecular EngineeringPolymers
A convergent synthesis of the C(1–17) AB-ring subunit of the spongistatins, exceedingly scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulfone coupling/methylenation.
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