Tetrahedron Letters · 1997 · 55 citations · 26 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryMacrocycle SynthesisMacrocyclic Drug DesignRetrosynthetic AnalysisMacrocycle DiversificationMacrocycle Library SynthesisMacrocycle Scaffold DesignMacrocyclic Scaffold DesignPolyether SynthesisSpirocyclic Scaffold DiversificationSpirocyclic ScaffoldsSpiroheterocycle Synthesis
A convergent synthesis of the C(1–17) AB-ring subunit of the spongistatins, exceedingly scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulfone coupling/methylenation.
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