Concepedia

A Convenient Synthesis of 3-Benzoylisoxazoles by 1,3-Dipolar Cycloaddition

Hiroyuki Kai, Minoru Tomida, Toru Nakai, Akira Takase

Heterocycles · 2002 · 10 citations · 11 references

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Abstract

A convenient, efficient method for the preparation of 3-benzoylisoxazoles is described.Nitrile oxides generated in situ from phenylglyoxylohydroxamyl chlorides and NaHCO 3 in isopropyl alcohol smoothly react with dipolarophiles at room temperature to provide the cycloadducts.

References

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Anti-influenza Virus Activities of 2-Alkoxyimino-N-(2-isoxazolin-3-ylmethyl)acetamides

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