Biyouxanthones A - D, Prenylated Xanthones from Roots of Hypericum chinense

Abstract

Four new prenylated xanthones, biyouxanthones A -D (1 -4), were isolated from roots of Hypericum chinense.The gross structures of 1 -4 were elucidated from spectroscopic data, and 2 was assigned as a racemate by chiral HPLC analysis.Biyouxanthones A (1) and B (2) exhibited anti-viral activity against hepatitis C virus (HCV).2][3][4] In our continuing search for bioactive compounds from Hypericum spp, 5 three new prenylated xanthones possessing 2-hydroxycyclohexa-2,4-dienone moiety, biyouxanthones A -C (1 -3), and one new prenylated xanthone having a 5-methyl-2-(prop-1-en-2-yl)hex-4-enyl group, biyouxanthone D (4), were isolated from roots of H. chinense.In this paper, we describe the isolation, structure elucidation of 1 -4 and anti-HCV activity of 1 and 2.