Concepedia

Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition

Ganna Leonenko, Maryam Shoai, Eftychia Bellou, Rebecca Sims, Julie Williams, John Hardy, Valentina Escott‐Price

Annals of Neurology · 2019 · 118 citations · 25 references

DOIFull text

Open access

Abstract

The results showed different pattern of APOE contribution in PRS risk predictions of AD/MCI and amyloid deposition. Our study suggests that APOE mostly contributes to amyloid accumulation and the PRS affects risk of further conversion to AD. ANN NEUROL 2019;86:427-435.

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25

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