Concepedia

A New Total Synthesis of the Zinc Matrixmetalloproteinase Inhibitor Ageladine A Featuring a Biogenetically Patterned 6π-2-Azatriene Electrocyclization

Matthew L. Meketa, Steven M. Weinreb

Organic Letters · 2007 · 46 citations · 10 references

DOI

Concepts

Abstract

[reaction: see text] A convergent second generation total synthesis of the heterocyclic marine sponge metabolite ageladine A has been achieved by using a biomimetically inspired 6pi-2-azatriene electrocyclization as the key step for formation of the imidazolopyridine moiety.

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