Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge <i>Agelas </i><i>n</i><i>akamurai</i>

Abstract

A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.