Concepedia

Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR

Feng Du, Chenyang Qiao, Xiaowei Li, Zhangqian Chen, Hao Liu, Shengda Wu, Zhaoyan Qiu, Meirui Qian, Dean Tian, Kaichun Wu,

Theranostics · 2019 · 52 citations · 31 references

DOIFull text

Open access

Concepts

Abstract

: FOXK2 serves as a prognostic biomarker in CRC. Cetuximab can block the EGF-NF-κB-FOXK2-EGFR feedback loop and suppress CRC metastasis.

References

31

Cancer statistics, 2018

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2018 · 17K citations · Full text

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The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution

James Briggs, Caleb Weinreb, Daniel E. Wagner et al. · Science · 2018 · 622 citations · Full text

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DNA-dependent formation of transcription factor pairs alters their binding specificity

Arttu Jolma, Yimeng Yin, Kazuhiro R. Nitta et al. · Nature · 2015 · 598 citations

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MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

Keun Hur, Yuji Toiyama, Masanobu Takahashi et al. · Gut · 2012 · 552 citations

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A Transient, EMT-Linked Loss of Basement Membranes Indicates Metastasis and Poor Survival in Colorectal Cancer

Simone Spaderna, Otto Schmalhofer, Falk Hlubek et al. · Gastroenterology · 2006 · 471 citations · Full text

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