Pure and Applied Chemistry · 2012 · 15 citations · 5 references
Alaskan Butter ClamSaxidomus GiganteusBiochemistryMedicineNatural SciencesNeurotransmitterNatural DerivativesIon ChannelsNeurotransmissionMicrobiologyMolecular NeurobiologyNervous SystemChemical BiologyPharmacologyNeurochemistrySynthetic ChemistryBiomolecular Engineering
Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus , inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)-decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
5