Synthesis of D-Ring Functionalized and D-Benzo/Hetero-Annulated Estrone Derivatives via α-Oxoketene Dithioacetal

Abstract

Synthesis and chemical transformation of the α-oxoketene dithioacetal, derived from estrone methyl ether, leading to new D-ring functionalized (4 and 6), D-benzo- (8), D-naphtho- (10 and 11) and D-hetero-annulated (12-14) derivatives are described.