Chemoenzymatic route to β-blockers via 3-hydroxy esters

Quantitative analyses of biochemical kinetic resolutions of enantiomers

Ching Shih Chen, Yoshitaka Fujimoto, Gary Girdaukas et al. · Journal of the American Chemical Society · 1982 · 2.6K citations

Natural Sciences, Biochemistry, Chemistry +9

A rule to predict which enantiomer of a secondary alcohol reacts faster in reactions catalyzed by cholesterol esterase, lipase from Pseudomonas cepacia, and lipase from Candida rugosa

Romas J. Kazlauskas, Alexandra N. E. Weissfloch, Aviva T. Rappaport et al. · The Journal of Organic Chemistry · 1991 · 945 citations

Life Sciences, Biochemistry, Chemistry +11

Lipase-catalyzed irreversible transesterification using enol esters: Resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propranolol

Y.‐F. WANG, Shui‐Tein Chen, Kevin K.‐C. Liu et al. · Tetrahedron Letters · 1989 · 117 citations

Natural Sciences, Biochemistry, Chemistry +11

Practical chemoenzymic synthesis of both enantiomers of propranolol

H. S. Bevinakatti, A. A. Banerji · The Journal of Organic Chemistry · 1991 · 113 citations

Pharmacy, Chemistry, Pharmacology +5

Highly efficient lipase-catalyzed asymmetric synthesis of chiral glycerol derivatives leading to practical synthesis of s-propranolol

Yoshiyasu Terao, Masakazu Murata, Kazuo Achiwa et al. · Tetrahedron Letters · 1988 · 95 citations

Life Sciences, Biotechnology, Chemistry +8