Highly efficient lipase-catalyzed asymmetric synthesis of chiral glycerol derivatives leading to practical synthesis of s-propranolol

LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS

Jacques Benveniste, Peter M. Henson, Charles G. Cochrane · The Journal of Experimental Medicine · 1972 · 1.2K citations · Full text

Life Sciences, Immunology, Pathology +17

Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Constantinos A. Demopoulos, R. Neal Pinckard, D J Hanahan · Journal of Biological Chemistry · 1979 · 1.2K citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Optical Isomers of Propranolol

R. HOWE, R. G. Shanks · Nature · 1966 · 364 citations

Natural Sciences, Chemistry, Pharmacology +6

Total synthesis of (R)-glycerol acetonide and the antiepileptic and hypotensive drug (-)-.gamma.-amino-.beta.-hydroxybutyric acid (GABOB): use of vitamin C as a chiral starting material

Michael E. Jung, Teresa J. Shaw · Journal of the American Chemical Society · 1980 · 238 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Asymmetric epoxidation of allyl alcohol: efficient routes to homochiral .beta.-adrenergic blocking agents

Janice M. Klunder, Soo Y. Ko, K. Barry Sharpless · The Journal of Organic Chemistry · 1986 · 180 citations

Natural Sciences, Chemistry, Pharmacology +8