Epicalyxin F and Calyxin I: Two Novel Antiproliferative Diarylheptanoids from the Seeds of<i>Alpinia</i><i>b</i><i>lepharocalyx</i>

Abstract

[formula: see text] Epicalyxin F (1) and calyxin I (2), two novel diarylheptanoids, were isolated from a residual fraction of an EtOH extract of Alpinia blepharocalyx. Calyxin I (2) represented a new carbon skeleton, and epicalyxin F (1) possessed potent antiproliferative activity toward HT-1080 fibrosarcoma and colon 26-L5 carcinoma with ED50 values of 1.71 and 0.89 microM, respectively.