Facile Synthesis of Functionalised β-Lactones; Novel Cyclisations of Chromium Carbene Complexes with Propargylic Alcohols

Abstract

All articles of this category Thermal reactions of readily available chromium carbene complexes and propargylic alcohols in the presence of acetic anhydride and triethylamine provide new and efficient routes into functionalised β-lactones; this unprecedented Cr-mediated cyclisation process has been shown to be possible with a series of (3 y -1 y ) propargylic alcohols. Chromium carbene complexes - β-Lactones - Propargylic alcohols - Lactonisation - Vinyl ketene