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Practical One-Step Synthesis of Koga's Chiral Bases
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2001
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Combinatorial ChemistryAsymmetric CatalysisMedicinal ChemistryNovel DiaminesEngineeringNovel OrganocatalystsNatural SciencesOrganic ChemistryChemistryPractical One-step SynthesisS Original RouteSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringChiral Bases
A simple, efficient and practical method for the preparation of Koga"s chiral bases is described. The method involves attack of an amine on a styrene oxide-derived aziridinium ion and has allowed the synthesis of novel diamines which cannot be prepared using Koga"s original route.