Synthesis of 2-Dimethylaminobenzazoles via a Guanidine Intermediate: Reaction of 2-Substituted Aniline Derivatives with 2-Chloro-1,1,3,3-tetramethylform-amidinium Chloride

Abstract

Reactions of 2-aminophenols, 2-aminothiophenol and o-phenylenediamines with 2-chloro-1,1,3,3-tetramethylformamidinium chloride proceeded easily via cyclization of guanidine intermediates to give the corresponding benzazoles having a dimethylamino group at 2-position.