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Aryl- and Heteroaryl-Alkyne Coupling Reactions Catalyzed by Palladium on Carbon and CuI in an Aqueous Medium

79

Citations

0

References

1995

Year

Abstract

A protocol for the efficient coupling of alkynes with aryl and heteroaryl substrates with a Pd/C-CuI-PPh3 catalyst system in aqueous media has been developed. These conditions are tolerant of a variety of unprotected functional groups. Reactions which demonstrate the generality and scope of this methodology are reported.