One-Pot Multicomponent Cascade Reaction of <i>N,S</i>-Ketene Acetal: Solvent-Free Synthesis of Imidazo[1,2-<i>a</i>]thiochromeno[3,2-<i>e</i>]pyridines

Abstract

Unprecedented imidazo[1,2-a]thiochromeno[3,2-e]pyridines have been synthesized via a three-component cascade reaction under solvent-free conditions. This one-pot transformation involving multiple steps and not requiring the use of transition metal catalysts constructs three new C-C bonds, two C-N bonds, one C-S bond, and three new rings with all reactants efficiently utilized.