Enantioselective Transesterifications Using Immobilized, Recombinant <i>Candida antarctica</i> Lipase B: Resolution of 2-Iodo-2-cycloalken-1-ols

Abstract

Five- to seven-membered 2-iodo-2-cycloalken-1-ols were resolved by enantioselective transesterifications with isopropenyl acetate in hexane catalyzed by Candida antarctica B lipase; product (R)-acetates and recovered (S)-alcohols has ee's >95%. Related studies involving 2-bromo-2-cyclohexen-1-ol, hydrolyses of 2-halo-2-cycloalkenyl acetates and use of Pseudomonas cepacia lipase are described.