Synthesis · 2003 · 70 citations · 0 references
Natural SciencesChemistryCatalysisOrganic ChemistryAddition ReactionsCatalyst PreparationCatalyst SynthesisCatalytic MaterialsHeterocycle SynthesisOrganic SynthesisAsymmetric Catalyst DesignChiral Catalyst DesignEnantioselective CatalysisEnantioselective Catalyst DesignEnantioselective SynthesisKetonesNucleophilic CatalysisNucleophilic Reactivity
The identification and development of a catalyst for the enantioselective nucleophilic addition of a trifluoromethyl anion to a ketone is described. An easily prepared cinchonine-derived catalyst was used in amounts as low as 4 mol% to afford enantiomeric excess as high as 92%.