Concepedia

Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene™

Thomas W. Bousfield, Katharine P. R. Pearce, Simbarashe B. Nyamini, Athanasios Angelis-Dimakis, J. E. Camp

Green Chemistry · 2019 · 110 citations · 65 references

DOIFull text

Open access

Concepts

Abstract

Cyrene™ as a bio-alternative dipolar aprotic solvent: a waste minimizing and molar efficient protocol for the synthesis of amides from acid chlorides and primary amines in the bio-available solvent Cyrene™ is disclosed.

References

65

CHEM21 selection guide of classical- and less classical-solvents

Denis Prat, A.S. Wells, John Hayler et al. · Green Chemistry · 2015 · 2.1K citations · Full text

, , +10

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Dean G. Brown, Jonas Boström · Journal of Medicinal Chemistry · 2015 · 2K citations · Full text

, , +11

What is a green solvent? A comprehensive framework for the environmental assessment of solvents

Christian Capello, Ulrich Fischer, Konrad Hungerbühler · Green Chemistry · 2007 · 1.9K citations

, , +13

Key green chemistry research areas—a perspective from pharmaceutical manufacturers

David J. C. Constable, Peter J. Dunn, John Hayler et al. · Green Chemistry · 2007 · 1.5K citations

, , +17

Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

Richard K. Henderson, Concepción Jiménez‐González, David J. C. Constable et al. · Green Chemistry · 2011 · 1.1K citations

, , +13