Chemical and Pharmaceutical Bulletin · 1995 · 23 citations · 0 references
MedicineMedicinal ChemistryPharmacologyNeurochemistryNeuropharmacologyStructure-activity RelationshipsLipid MetabolismLipid PeroxidationNeurochemical PharmacologyNeuroprotectionNeuroprotective PharmacologyStructure-activity Relationship AnalysisAntioxidant PharmacologyChemical Structure-activity RelationshipsMechanisms Of Cyanide ToxicityPharmacological PotencyPharmacological ScreeningSynthetic Antioxidants
A series of 1,2,3,4-tetrahydro-beta-carbolines has been synthesized and evaluated for cerebral protecting effects against lipid peroxidation and potassium cyanide intoxication in mice. Most of the compounds synthesized had potent effects against lipid peroxidation. Among them, 1-(3,5-dimethoxyphenyl)-2-propyl-1,2,3,4-tetrahydro-beta-carboline (22) was found to have a combination of potent effects against both lipid peroxidation and potassium cyanide intoxication. Structure-activity relationships are discussed.