Synthesis and antibacterial screening of new 4‐((5‐(difluoromethoxy)‐1<i>H</i>‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinoline derivatives

Abstract

Abstract magnified image A method for the synthesis of previously unknown heterocyclic systems 4‐((5‐(difluoromethoxy)‐1 H ‐benzo[d]imidazol‐2‐ylthio)methyl)tetrazolo[1,5‐a]quinolines derivatives 6 has been developed based on various substitutes 2‐chloroquinoline‐3‐carbaldehydes 1 via the consecutive steps of conversion into tetrazolo[1,5‐a]quinoline‐4‐carbaldehyde 2 on treatment with sodium azide which upon reduction to the corresponding alcohol derivatives 3 , conversion to chlorides 4 with thionyl chloride followed by the coupling with 5‐(difluoromethoxy)‐1 H ‐benzo[d]imidazole‐2‐thiol 5 . The synthesized titled compounds ( 6a , 6b , 6c , 6d , 6e ) were screened for the antibacterial activity against gram positive and gram negative bacteria. J. Heterocyclic Chem., (2010).