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Preparation of Highly Functionalized Imidazoles from α-Azidoacetonitrile: X-ray Crystal Structure of 4-Methoxy-2-methylamino-5-methylthiocarbamoylimidazole
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1995
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Combinatorial ChemistryCrystal StructureEngineeringHighly Functionalized ImidazolesCorresponding Imidazole 5Structure ElucidationX-ray Diffraction MethodsOrganic ChemistryX-ray Crystal StructureChemistryCrystallographySynthetic ChemistryBiomolecular Engineering
The Pinner salt 2 derived from α-azidoacetonitrile by sequential treatment with triethylamine, triphenylphosphine and acyl chlorides or isothiocyanates was converted into the corresponding imidazole 5 or 6, respectively. The crystal structure of 6a has been determined by X-ray diffraction methods. Dimers of centrosymmetrically related molecules, linked by N-H...N bonds, join together to infinite chains through N-H...S=C halogen interactions.