One-pot, cis-selective synthesis of α-substituted β-trimethylsilyl-α,β-epoxyesters from α-ketoesters and diazo(trimethylsilyl)methyl magnesium bromide

Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists

Wolfgang Froestl, Stuart J. Mickel, G. VON SPRECHER et al. · Journal of Medicinal Chemistry · 1995 · 206 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria.

Timothy C. Kiorpes, David C. Hoerr, Winston Ho et al. · Journal of Biological Chemistry · 1984 · 152 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

An enantio- and stereocontrolled synthesis of (–)-mycestericin E via cinchona alkaloid-catalyzed asymmetric Baylis–Hillman reaction

Yoshiharu Iwabuchi, Mariko Furukawa, Tomoyuki Esumi et al. · Chemical Communications · 2001 · 148 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

An enantio- and stereocontrolled route to epopromycin B via cinchona alkaloid-catalyzed Baylis–Hillman reaction

Yoshiharu Iwabuchi, Tatsuya Sugihara, Tomoyuki Esumi et al. · Tetrahedron Letters · 2001 · 96 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +3

Stereoselective synthesis of epoxides by reaction of donor/acceptor-substituted carbenoids with α,β-unsaturated aldehydes

Huw M. L. Davies, Jason DeMeese · Tetrahedron Letters · 2001 · 87 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9