How common are single gene mutations as a cause for lacunar stroke?

Abstract

Rare monogenic variants account for about 1.5% of younger onset lacunar stroke. Most are cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy variants, but the second most common gene affected is <i>HTRA1.</i> A high-throughput sequencing technology platform is an efficient, reliable method to screen for such mutations.